Combination Therapy for Enterococcal Endocarditis
نویسندگان
چکیده
منابع مشابه
Antimicrobial therapy of experimental enterococcal endocarditis.
The successful therapy of enterococcal endocarditis requires prolonged administration of synergistic antibiotic combinations. Controversy has arisen regarding optimal therapy (i) when the organism possesses high-level streptomycin resistance, and (ii) when the patient is allergic to penicillin. This study examines these questions in vitro and in a rabbit model of enterococcal endocarditis. The ...
متن کاملFailure of combination therapy with daptomycin and synergistic ceftriaxone for enterococcal endocarditis.
Department of Pharmacy, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Laboratory Medicine, Medical Microbiology Division, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, G227–2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Department of Infectious Diseases, Island Health, 1952...
متن کاملContinuous-infusion ampicillin therapy of enterococcal endocarditis in rats.
Intermittent administration of ampicillin alone has resulted in high failure rates in previously described animal models of enterococcal endocarditis. We developed a rat model of enterococcal endocarditis which permits comparison of continuous intravenous infusion of ampicillin with intramuscular therapy. Continuous low-dose ampicillin infusion (450 mg/kg [body weight] per day) was compared wit...
متن کاملCombination antibiotic therapy for infective endocarditis.
Despite the availability of new and potent antibiotics, modern echocardiography, and advanced surgical techniques, infective endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due...
متن کاملSparfloxacin and clinafloxacin alone or in combination with gentamicin for therapy of experimental ampicillin-resistant enterococcal endocarditis in rabbits.
Sparfloxacin and clinafloxacin alone and in combination with gentamicin, were evaluated for the treatment of experimental endocarditis in rabbits caused by ampicillin-resistant enterococci. Clinafloxacin was tested against Enterococcus faecalis strain WH245, a beta-lactamase producer lacking high-level gentamicin resistance (MIC 12.5 mg/L). Sparfloxacin was tested against Enterococcus faecium s...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2013
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/cit338